Hydantoins: Synthesis, properties and anticonvulsant activity

Abstract

Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.Hidantoin je petoclani ciklicni ureid koji je sadrzan u brojnim bioloski aktivnim jedinjenjima kao sto su antiaritmici, antikonvulzivi i antitumor agensi. U ovom radu su opisani postupci dobijanja derivata hidantoina, njihova fizicka svojstva i reaktivnost. Prikazani su najcesce korisceni antikonvulzivi iz grupe hidantoina, a razmatran je i uticaj strukture na antikovulzivnu aktivnost razlicitih derivata sa aspekta lipofilnosti i mogucnosti uspostavljanja vodonicnih veza.