Background:Interleukin-10 (IL-10) is a inhibiting inflammatory cytokine that plays an important role in immune suppressive microenvironment in multiple myeloma (MM). Whether the level of serum IL-10 could predict treatment response and survival outcomes or not needs to be investigated in MM patients.Methods:The level of IL-10 in serum was measured using enzyme-linked immunosorbent assay in 188 patients with newly diagnosed MM.Results:The best cutoff value for IL-10 in predicting survival is 169.69 pg ml -1 with an area under the curve (AUC) value of 0.747 (P<0.001). In all, 92 patients (48.9%) were classified as high-IL-10 group (>169.96 pg ml -1) and 96 patients (51.1%) as low-IL-10 group (≤169.96 pg ml -1). The overall response rate (ORR) was 79.2% in low-IL-10 group, significantly higher than that in high-IL-10 group (53.3%, P<0.001). Patients in low-IL-10 group had significantly better survival compared with those in high-IL-10 group (3-year PFS rate: 69.3% vs 13.3%, P<0.001; 3-year OS rate: 93.6% vs 51.9%, P<0.001). Multivariate analysis revealed that serum IL-10 level >169.96 pg ml -1 at diagnosis and certain cytogenetic abnormalities were two adverse factors for PFS and OS.Conclusions:Our data suggest that serum IL-10 at diagnosis is a novel, powerful predictor of prognosis for MM.
CITATION STYLE
Wang, H., Wang, L., Chi, P. D., Wang, W. D., Chen, X. Q., Geng, Q. R., … Lu, Y. (2016). High level of interleukin-10 in serum predicts poor prognosis in multiple myeloma. British Journal of Cancer, 114(4), 463–468. https://doi.org/10.1038/bjc.2016.11
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