Solvent free and catalyst free synthesis of Octahydroquinazolinone via grindstone chemistry: A total green approach

Abstract

Octahydroquinazolinone is a heterocyclic compound of immense importance in the field of medicinal and pharmaceutical chemistry. Although a large number of methods are reported in literature for synthesis of Octahydroquinazolinone via one pot multi component cyclo condensation reaction of dimedone, thio urea and aromatic aldehydes, grindstone synthesis of this heterocyclic compound is not reported till date. Hereby a green method is reported for the very first time for grindstone synthesis of Octahydroquinazolinone in a completely solvent free and catalyst free condition. A series of derivatives of this heterocyclic compounds were synthesized using various derivatives of aromatic aldehydes as reactants. After completion of reaction the crude product was re-crystallized from hot ethanol to obtain pure compound which were further characterized by melting point, IR and NMR spectroscopy.