Eosinophilic dermatosis of hematologic malignancy

Abstract

We report a 68-year-old woman with chronic lymphocytic leukemia, who developed numerous, pruritic, edematous, and vesicobullous skin lesions of the face and extremities over the course of several months. The diagnosis of eosinophilic dermatosis of hematologic malignancy (EDHM) was made based on the clinical history and histopathologic features. Owing to the possible link between EDHM and a more aggressive underlying CLL, she was started again on chemotherapy. This case serves as a reminder that, although the precise pathogenesis of EDHM remains unclear, the paraneoplastic disorder is the result of immune dysregulation. Patients who develop EDHM should undergo prompt hematologic/oncologic evaluation.