Hypersensitivity reaction to dapsone. Four case reports

Abstract

Hypersensitivity reaction to the most commonly used antileprosy drug, dapsone, is becoming an increasingly important problem in the field of leprosy treatment. This undesired reaction to dapsone is more common than was thought previously. In this article 4 cases seen at the Nonsombun Leprosy Hospital during the years 1982-83 are reported. The 4 leprosy patients (2 cases of BL, 1 case of BT and 1 case of TT) presented with cutaneous and systemic manifestations of hypersensitivity to dapsone. The diagnosis was confirmed by trial dose in 3 cases.