Leaf extracts from Nitraria retusa promote cell population growth of human cancer cells by inducing apoptosis

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Abstract

Background: In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.Methods: Apoptosis of the human chronic myelogenous erythroleukaemia (K562) was evidenced by investigating DNA fragmentation, PARP cleavage and caspases 3 and 8 inducing activities, in the presence of N. retusa extracts.Results: Our study revealed that the tested extracts from N. Retusa contain many useful bioactive compounds. They induced in a time-dependent manner the apoptosis the tested cancerous our cell line. This result was confirmed by ladder DNA fragmentation profile and PARP cleavage, as well as a release in caspase-3 and caspase-8 level.Conclusion: Our results indicate that the tested compounds have a significant antiproliferative effect which may be due to their involvement in the induction of the extrinsic apoptosic pathway. © 2011 Boubaker et al; licensee BioMed Central Ltd.

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Boubaker, J., Bhouri, W., Sghaier, M. B., Bouhlel, I., Skandrani, I., Ghedira, K., & Chekir-Ghedira, L. (2011). Leaf extracts from Nitraria retusa promote cell population growth of human cancer cells by inducing apoptosis. Cancer Cell International, 11. https://doi.org/10.1186/1475-2867-11-37

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