Capsaicin

Abstract

Capsaicin is extracted from chili pepper (Capsicum). It is one of the main pungent components in Capsicum fruits, which is one of the most popular and widely used spices in the world. Pharmacological research shows that pepper has beneficial effects on the digestive, cardiovascular, and endocrine system, as well as analgesia. Capsaicin can act on sensory nerve C primary afferent fibers, bind the end of the neuronal TRPV1 receptor. In clinical practice, capsaicin is mainly used for topical administration. In 2009, the US FDA approved the first capsaicin prescription patch with high concentration for the treatment of postherpetic neuralgia. At present, most countries have capsaicin prescription drugs on market, but clinical indications are limited to the treatment of pain. The capsaicin drug's R&D is relatively slow. If less irritated irritant capsaicin derivative can be obtained from structure modification, its development prospects would be attractive.