Background and objective: Fetuin-A is a liver-derived circulating protein that is associated with insulin resistance and diabetes. The objective of this systematic review and meta-analysis of published observational studies was to investigate mean levels of fetuin-A in T2D patients and the relationship between blood fetuin-A levels and T2D risk. Materials and methods: PubMed, Embase, Google Scholar, Web of Science, and The Cochrane Library were systematically searched for potential relevant studies up to 1 December 2016. Natural logarithm-transformed estimate risks, standard mean differences on the basis of Hedges’s adjusted g, and 95% confidence intervals (CIs) were calculated for all eligible studies and were combined to measure the pooled data using random-effects model. Results: A total of 32 studies including 27 case–control and 5 cohort studies were included in the current study. Fetuin-A levels in T2D patients were significantly higher than control groups [Hedges’ g = 1.73, 95% CI (1.25–2.22), P < 0.001], with significant heterogeneity across studies (P < 0.001, I2 = 98.46%). Findings from meta-analyses of cohort studies showed a statistically significant association between fetuin-A levels and T2D risk [rate ratio = 1.62, 95% CI (1.26–2.08), P < 0.001], with no significant heterogeneity (P = 0.10, I2 = 46.06%). Conclusion: We found a significant relationship between the fetuin-A levels with T2D risk. Although fetuin-A may be as a potential screening and prediction biomarker or a therapeutic target in T2D patients, further studies are required in this regard.
CITATION STYLE
Roshanzamir, F., Miraghajani, M., Rouhani, M. H., Mansourian, M., Ghiasvand, R., & Safavi, S. M. (2018, January 1). The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies. Journal of Endocrinological Investigation. Springer International Publishing. https://doi.org/10.1007/s40618-017-0697-8
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