The structure of the previously reported new antiinflammatory agent (1, FK3311) was chemically modified in an attempt to find novel compounds with more potent and broader-spectrum activities. Some 2’-(phenylthio) and 2’-(phenylamino)methanesulfonanilides (2 and 3), in particular those bearing an electron-attracting substituent at the 4’-position, potently inhibited adjuvant arthritis in rats as well as collagen-induced arthritis in mice when administered orally. 4‘-Carbamoyl-2’-(2,4-difluorophenylthio)methanesulfonanilide (3b), which was selected as a candidate for further development from among the compounds synthesized herein, exhibited activity in reducing arthritis in a spontaneous autoimmune disease model (MRL/lpr mice) within the dose range of 10—100 mg/kg (p.o.). © 1993, The Pharmaceutical Society of Japan. All rights reserved.
CITATION STYLE
Nakamura, K., Tsuji, K., Konishi, N., Okumura, H., & Matsuo, M. (1993). Studies on Antiinflammatory Agents. II.1) Synthesis and Pharmacological Properties of 2’-(Phenylthio)methanesulfonanilides and Related Derivatives. Chemical and Pharmaceutical Bulletin, 41(5), 894–906. https://doi.org/10.1248/cpb.41.894
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