Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.

Abstract

The time-kill studies using pargamicin A against Staphylococcus aureus and Enterococcus faecalis were performed. The effects of the incorporation of radioactive precursors into macromolecules, membrane potential and function using fluorescent dyes were also examined. These studies revealed that rapid bactericidal activity of pargamicin A correlates with the perturbation of bacterial cell membrane potential and membrane function. © 2010 Japan Antibiotics Research Association All rights reserved.