Flavonoids derived from Exocarpium Citri Grandis inhibit LPS-induced inflammatory response via suppressing MAPK and NF-κB signalling pathways

23Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Exocarpium Citri Grandis (ECG) is used as an antitussive and anti-inflammatory agent in traditional Chinese medicine. However, the mechanism of its anti-inflammatory effect remains unknown. In this study, flavonoids of ECG (FECG) were extracted to investigate the anti-inflammatory effect using a RAW264.7 macrophage model. The results suggested that FECG could remarkably inhibit the production of nitric oxide (NO). Meanwhile, FECG decreased the mRNA and protein expression of inflammatory cytokines including tumour necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), while showed an opposite effect on interleukin-10 (IL-10). Furthermore, FECG suppressed the phosphorylation of p38 (p38 kinase), JNK (c-Jun N-terminal kinase), ERK (extracellular signal-regulated kinase) and NF-κB. Taken together, our results indicated that FECG might regulate the activation of MAPK and NF-κB signalling pathways to exert anti-inflammatory effects. This study provides some insights into the mechanism underlying the anti-inflammatory activity of ECG, which may facilitate a better application of ECG.

Cite

CITATION STYLE

APA

Peng, Y., Hu, M., Lu, Q., Tian, Y., He, W., Chen, L., … Pan, S. (2019, January 1). Flavonoids derived from Exocarpium Citri Grandis inhibit LPS-induced inflammatory response via suppressing MAPK and NF-κB signalling pathways. Food and Agricultural Immunology. Taylor and Francis Ltd. https://doi.org/10.1080/09540105.2018.1550056

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free