NF-κB activation in peripheral blood mononuclear cells in neonatal asphyxia

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Abstract

Neonatal asphyxia results in hypoxic-ischaemic encephalopathy. Previous studies have demonstrated that brain hypoxia and ischaemia lead to the production of proinflammatory cytokines, including tumour necrosis factor-α (TNF-α), interleukin-1 (IL-1) and IL-6. Transcription factor NF-κB is essential for the expression of these cytokines. We examined whether or not NF-κB is activated in peripheral mononuclear cells (PBMC) in neonatal asphyxia by flow cytometry. In addition, we examined the relationship between NF-κB activation in PBMC and the neurological prognosis. Flow cytometry analysis demonstrated that the level of NF-κB activation in CD14+ monocytes/macrophages of the patients with asphyxia who had neurological sequelae was significantly higher than in the controls, and in the patients with asphyxia who survived (31.7 ± 7.2% versus 2.5 ± 0.9%, P = 0.008, and versus 1.6 ± 1.4%, P = 0.014, respectively). Our findings suggest that NF-κB activation in peripheral blood CD14+ monocytes/macrophages in neonatal asphyxia is important for predicting the subsequent neurological sequelae.

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Hasegawa, K., Ichiyama, T., Isumi, H., Nakata, M., Sase, M., & Furukawa, S. (2003). NF-κB activation in peripheral blood mononuclear cells in neonatal asphyxia. Clinical and Experimental Immunology, 132(2), 261–264. https://doi.org/10.1046/j.1365-2249.2003.02127.x

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