Proliferation Requirements of Cytomegalovirus-Specific, Effector-Type Human CD8+ T Cells

  • van Leeuwen E
  • Gamadia L
  • Baars P
  • et al.
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Abstract

Two prototypic types of virus-specific CD8+ T cells can be found in latently infected individuals: CD45R0+CD27+CCR7− effector-memory, and CD45RA+CD27−CCR7− effector-type cells. It has recently been implied that CD45RA+CD27−CCR7− T cells are terminally differentiated effector cells and as such have lost all proliferative capacity. We show in this study, however, that stimulation of CMV-specific CD45RA+CD27−CCR7− T cells with their cognate peptide in concert with either CD4+ help or IL-2, IL-15, or IL-21 in fact induces massive clonal expansion. Concurrently, these stimulated effector T cells change cell surface phenotype from CD45RA to CD45R0 and regain CCR7, while effector functions are maintained. Our data imply that CD45RA+CD27−CCR7− effector-type T cells contribute to immunity not only by direct execution of effector functions, but also by yielding progeny in situations of viral reinfection or reactivation.

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APA

van Leeuwen, E. M., Gamadia, L. E., Baars, P. A., Remmerswaal, E. B., ten Berge, I. J., & van Lier, R. A. (2002). Proliferation Requirements of Cytomegalovirus-Specific, Effector-Type Human CD8+ T Cells. The Journal of Immunology, 169(10), 5838–5843. https://doi.org/10.4049/jimmunol.169.10.5838

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