Endocrine disorders and coeliac disease

Abstract

Coeliac disease (coeliac sprue, gluten-related enteropathy) is both digestive intolerance and an autoimmune disorder. It is a multifactorial disorder in which genetic, immune, environmental and metabolic factors seem to be most important in its pathogenesis. Because of the diversity of clinical symptoms and more frequent occurrence of this disease than was previously assumed, coeliac disease should be taken into consideration in general practice and specialty clinics (especially endocrinology). The aim of this review article is to present and discuss the associated endocrine disorders that are often the first symptoms of coeliac disease or can suggest its coexistence. Therefore, fast diagnosis and introduction of a glutenfree diet can completely withdraw some of the endocrine disorders, support their treatment and prevent the development of severe complications.