An action spectrum for the elicitation of erythema in skin persistently sensitized by photobound 8-methoxypsoralen

43Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Human skin can be rendered persistently photosensitive by topical application of aqueous 8-methoxypsoralen (8-MOP) and exposure to a suberythemogenic dose of more than 380 rim radiation. We report an action spectrum for the elicitation of phototoxic erythema induced by a second exposure of skin pretreated in this way. After correction for unsensitized skin erythema this action spectrum resembles the absorption spectrum of the 4′,5′-monoadduct of 8-MOP to DNA. This suggests that the monoadduct is the chromophore for erythema elicited by the second irradiation, and supports the DNA crosslink as the crucial photoproduct causing phototoxic erythema due to 8-MOP in human skin. © 1990.

Cite

CITATION STYLE

APA

Ortel, B., & Gange, R. W. (1990). An action spectrum for the elicitation of erythema in skin persistently sensitized by photobound 8-methoxypsoralen. Journal of Investigative Dermatology, 94(6), 781–785. https://doi.org/10.1111/1523-1747.ep12874639

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free