Bacteria commonly utilise a unique type of transporter, called Feo, to specifically acquire the ferrous (Fe2+) form of iron from their environment. Enterobacterial Feo systems are composed of three proteins: FeoA, a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. We provide a review of the current literature combined with a bioinformatic assessment of bacterial Feo systems showing how they exhibit common features, as well as differences in organisation and composition which probably reflect variations in mechanisms employed and function. © Springer 2006.
CITATION STYLE
Cartron, M. L., Maddocks, S., Gillingham, P., Craven, C. J., & Andrews, S. C. (2006). Feo - Transport of ferrous iron into bacteria. In BioMetals (Vol. 19, pp. 143–157). https://doi.org/10.1007/s10534-006-0003-2
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