Wake-up call for endothelial cells

Abstract

VEGF exhibits broad vascular functions by activation of its VEGFRs in endothelial cells. In this issue of Blood, Suehiro and colleagues show that VEGF-induced endothelial activities are mediated by activation of Egr-3 transcription factor and that Egr-3 is a potential therapeutic target for angiogenesis-related diseases.