Differentiation keeps skin cancer at bay

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Abstract

The cancer-suppressive mechanisms underlying a tissue’s response to spontaneous oncogenic mutations during homeostasis are largely unknown. A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.

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Kuri, P., & Rompolas, P. (2018, November 1). Differentiation keeps skin cancer at bay. Nature Cell Biology. Nature Publishing Group. https://doi.org/10.1038/s41556-018-0222-0

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