Relationship between fibroblast growth factor 19 and diabetic retinopathy in patients with type 2 diabetes mellitus

Abstract

Aim: This study aimed to evaluate whether fibroblast growth factor 19 (FGF19) is associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 357 patients with T2DM were investigated in this cross-sectional study. Logistic regression analysis was performed to assess the association between FGF19 level and diabetic retinopathy. Results: Serum FGF19 level was significantly lower in patients with diabetic retinopathy in those without diabetic retinopathy. The multivariable analysis revealed a significant association between serum FGF19 level and diabetic retinopathy (odds ratio for every 1 standard deviation increase in logarithmic value = 0.69, 95% confidence interval 0.51–0.94, p = 0.019). Conclusion: Serum FGF19 level was negatively associated with diabetic retinopathy in patients with T2DM.