Teaching enantioselectivity to C-H bond functionalizations: Initial steps of a rather long shot

Abstract

The direct functionalization of non-activated C-H bonds, especially in an enantioselective manner, requires metal catalysts equipped with ligands with specifically designed properties. Examples for asymmetric C(sp2)-H and C(sp3)-H functionalizations using palladium-and rhodium catalysts are shown. This work was rewarded by the 2012 Werner Prize of the Swiss Chemical Society. © Schweizerische Chemische Gesellschaft.