Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers

46Citations
Citations of this article
156Readers
Mendeley users who have this article in their library.

Abstract

The interplay between excitation and inhibition is crucial for neuronal circuitry in the brain. Inhibitory cell fractions in the neocortex and hippocampus are typically maintained at 15 to 30%, which is assumed to be important for stable dynamics. We have studied systematically the role of precisely controlled excitatory/inhibitory (E/I) cellular ratios on network activity using mice hippocampal cultures. Surprisingly, networks with varying E/I ratios maintain stable bursting dynamics. Interburst intervals remain constant for most ratios, except in the extremes of 0 to 10% and 90 to 100% inhibitory cells. Single-cell recordings and modeling suggest that networks adapt to chronic alterations of E/I compositions by balancing E/I connectivity. Gradual blockade of inhibition substantiates the agreement between the model and experiment and defines its limits. Combining measurements of population and single-cell activity with theoretical modeling, we provide a clearer picture of how E/I balance is preserved and where it fails in living neuronal networks.

Cite

CITATION STYLE

APA

Sukenik, N., Vinogradov, O., Weinreb, E., Segal, M., Levina, A., & Moses, E. (2021). Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers. Proceedings of the National Academy of Sciences of the United States of America, 118(12). https://doi.org/10.1073/pnas.2018459118

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free