An optimized mouse model of Staphylococcus aureus infected diabetic ulcers

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Objective: Diabetic foot infection (DFI) represents a major healthcare burden, for which treatment is challenging owing to the pathophysiological alterations intrinsic to diabetes and the alarming increase of antimicrobial resistance. Novel therapies targeting DFI are therefore a pressing research need for which proper models of disease are required. Results: Here, we present an optimized diabetic mouse model of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, that resemble key features of DFI, such as pathogen invasion through wound bed and surrounding tissue, necrosis, persistent inflammation and impaired wound healing. Thus, in a time-efficient manner and using simple techniques, this model represents a suitable approach for studying emerging therapies targeting DFI caused by MRSA.




Mendes, A. I., Peixoto, M. J., Marques, A. P., Pedrosa, J., & Fraga, A. G. (2022). An optimized mouse model of Staphylococcus aureus infected diabetic ulcers. BMC Research Notes, 15(1).

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