Pot economy in the synthesis of prostaglandin A1 and E 1 methyl esters

Abstract

Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.