Studies on the Constituents of Luffa Operculata Cogn. I. Isolation and Structures of Luperosides A—H, Dammarane-type Triterpene Glycosides in the Herb

Abstract

Eight dammarane-type triterpene glycosides named luperosides A—H were isolated from the dried herb of Luffa operculata cogn. (Cucurbitaceae). Their structures were determined on the basis of chemical and spectral evidence as follows. A: a 3,2O-bis-0-β-D-glucopyranoside of (20S)-dammar-24-ene-3β,7β,20-triol (Ag). B: a 2O-0-β-gentiobio-side of Ag. C: a 3-0-β-neohesperidoside-2O-0-β-D-glucopyranoside of Ag. D: a 3-0-β-D-glucopyranoside-2O-0-β-gentiobioside of Ag. E: a 3-0-β-neohesperidoside-2O-0-β-D-xylopyranosyl-(l-»6)-β-D-glucopyranoside of Ag. F: a 3-0-β-neohesperidoside-2O-0-β-gentiobioside of Ag. G: a 3-0-β-neohesperidoside-2O-0-β-gentiobioside of (20S)-dammar-23-ene-3β,7β,20,25-tetraol. H:3-0-β-neohesperidoside-2O-0-β-gentiobiosides of (20S, 24S and R)-dammar-25-ene-3β,7β,20,24-tetraols. © 1989, The Pharmaceutical Society of Japan. All rights reserved.