Antiinflammatory, analgesic and kinase inhibition activities of some acridine derivatives

Abstract

9-Chloro-2,4-(un)substituted acridines (1) on condensation with sulpha- diazine, sulphathiazole, and sulphaacetamide gave condensation products 3a-h. 3-Aryl-4-phenyl-2-imino-4-thiazolines (4) on condensation with 9-chloro-2,4-(un)substituted acridines (1) gave condensation products 5a-5o. Both 3a-3h and 5a-5o were puried by crystallization or by chromatography. Structures assigned to 3a-3h and 5a-5o are supported by correct spectral data. Antiinrammatory and analgesic activity screening of 3a, 3e, 3f and 5a-5c, 5e, 5g, 5i, 5m, 5n were carried out using carrageenin induced paw oedema and phenyl quinone writhing assay. Some of the compounds exhibited interesting antiinlammatory or analgesic activities. © Central European Science Journals. All rights reserved.