Objectives - To study changes in sex ratio, disease course, time from onset to diagnosis and age at diagnosis by year of birth in a well-defined population of multiple sclerosis (MS) patients. Materials and methods - Based on the Oslo MS Registry patients born from 1910 to 1980 with residence in Oslo at time of diagnosis were studied. Data were analyzed by 10-year intervals based on year of birth. Results - The female to male ratio increased significantly from 1.48 to 2.30 through seven decades. Also, the ratio of initial relapsing-remitting (RR-MS) to primary progressive (PP-MS) disease course increased significantly from 1.93 to 16.00. The time from onset to diagnosis and the mean age at diagnosis declined significantly during the same period. Conclusions - This study shows that there has been a change in MS sex ratio, disease course and age at diagnosis through a period of seven decades, suggesting an environmental factor mainly affecting women at a younger age and causing a RR-MS disease course. © 2009 John Wiley & Sons A/S.
CITATION STYLE
Celius, E. G., & Smestad, C. (2009). Change in sex ratio, disease course and age at diagnosis in Oslo MS patients through seven decades. Acta Neurologica Scandinavica, 120(SUPPL. 189), 27–29. https://doi.org/10.1111/j.1600-0404.2009.01208.x
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