Are metabolically normal but obese individuals at lower risk for all-cause mortality?

Abstract

OBJECTIVE - The clinical relevance of the metabolically normal but obese phenotype for mortality risk is unclear. This study examines the risk for all-cause mortality in metabolically normal and abnormal obese (MNOB and MAOB, respectively) individuals. RESEARCH DESIGN AND METHODS - The sample included 6,011 men and women from the Third National Health and Nutrition Examination Survey (NHANES III) with public-access mortality data linkage (follow-up = 8.7 ± 0.2 years; 292 deaths). Metabolically abnormal was defined as insulin resistance (IR) or two or more metabolic syndrome (MetSyn) criteria (excluding waist). RESULTS - A total of 30% of obese subjects had IR, and 38.4% had two or more MetSyn factors, whereas only 6.0% (or 1.6% of the whole population) were free from both IR and all MetSyn factors. By MetSyn factors or IR alone,MNOBsubjects (hazard ratio [HR]MetSyn 2.80 [1.18-6.65]; HR IR 2.58 [1.00-6.65]) and MAOB subjects (HRMetSyn 2.74 [1.46 -5.15]; HRIR 3.09 [1.55- 6.15]) had similar elevations in mortality risk compared with metabolically normal, normal weight subjects. CONCLUSIONS - Although a rare phenotype, obesity, even in the absence of overt metabolic aberrations, is associated with increased all-cause mortality risk. © 2009 by the American Diabetes Association.