Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T H 2, T H 17 and T H 22. Here we describe a distinct ILC subset similar to T H 1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt + ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation. © 2013 Nature America, Inc. All rights reserved.
CITATION STYLE
Bernink, J. H., Peters, C. P., Munneke, M., Te Velde, A. A., Meijer, S. L., Weijer, K., … Spits, H. (2013). Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nature Immunology, 14(3), 221–229. https://doi.org/10.1038/ni.2534
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