Abstract
Multicentric lymphoma was diagnosed in a two-year-old dog with respiratory distress, dysorexia, abdominal enlargement and generalized lymphadenopathy. Immunohistochemical examination showed Tcell origin with CD3+ e CD79- expression. After five weeks, progressive neurological deficits and neoplastic lymphocytes were identified in the cerebrospinal fluid. Histopathological examination showed neoplastic cell invasion in the spleen, lymph nodes, cerebrum and cerebellum.
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Aptekmann, K. P., Okamoto, C. E., Campos, K. C. H., & Takahira, R. K. (2005). Multicentric lymphoma with metastasis in the central nervous system in a dog. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, 57(3), 307–311. https://doi.org/10.1590/S0102-09352005000300005
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