A straight neutrophil path to healthy aging?

Abstract

In this issue of Blood, Sapey et al1 report that the human polymorphonuclear neutrophil leukocyte (or neutrophil) undergoes an age-related loss of its ability to migrate up chemotactic gradients, a functional defect that seems causally related to alterations in the polyphosphoinositide pathway.2. © 2014 by The American Society of Hematology.