Vitreoretinal interface and inner limiting membrane

Abstract

The vitreoretinal interface is the site of many pathogenic events associated with sequences that lead to vision loss. The interface consists of a complex formed by the internal limiting lamina of the retina, commonly called the internal limiting membrane (ILM), the posterior vitreous cortex, and an intervening extracellular matrix that is thought to be responsible for vitreoretinal adhesion (Figure II.E-1). Changes in each of these three components occur with aging and in certain diseases, such as myopia and diabetes. These aging and disease-related changes contribute a variety of vitreoretinal disorders. There are special interfaces between vitreous and the optic disc.