Tyrosine kinase signalling in breast cancer. Epidermal growth factor receptor and c-Src interactions in breast cancer

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Abstract

Both the non-receptor tyrosine kinase, c-Src, and members of the epidermal growth factor (EGF) receptor family are overexpressed in high percentages of human breast cancers. Because these molecules are plasma membrane-associated and involved in mitogenesis, it has been speculated that they function in concert with one another to promote breast cancer development and progression. Evidence to date supports a model wherein c-Src potentiates the survival, proliferation and tumorigenesis of EGF receptor family members, in part by associating with them. Phosphorylation of the EGF receptor by c-SRC is also critical for mitogenic signaling initiated by the EGF receptor itself, as well as by several G-protein coupled receptors (GPCRs), a cytokine receptor, and the estrogen receptor. Thus, c-Src appears to have pleiotropic effects on cancer cells by modulating the action of multiple growth-promoting receptors.

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Biscardi, J. S., Ishizawar, R. C., Silva, C. M., & Parsons, S. J. (2000). Tyrosine kinase signalling in breast cancer. Epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Research. https://doi.org/10.1186/bcr55

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