Other challenging therapies

Abstract

Previous chapters described initial and rescue treatment for patients with Kawasaki disease. Other immunosuppressive agents, such as biological agents, methotrexate, cyclophosphamide, and plasma exchange, may also be effective for patients with Kawasaki disease. However, most of these agents have not been carefully evaluated for their efficacy in suppressing inflammation due to Kawasaki disease and preventing formation of coronary artery lesions, and most of the present evidence is from case reports or case series. Further research is needed before recommendations can be developed for these agents.