Ischemic stroke pathophysiology and cell therapy

Abstract

Current evidence shows great promise for stem cell transplantation as a new strategy for stroke. However, stem cell transplantation for stroke is still in its infancy, with many issues that need to be addressed in order to achieve the full potential of stem cell therapy for stroke. Among the major hurdles for successful clinical translation is determining the time window, stem cell type selection, delivery route, and underlying cellular and molecular mechanisms. In this chapter, we attempt to review the basic knowledge of pathophysiology and summarize the different stem cells for stroke treatment.