Comparison of β enolase and myoglobin as histological markers of rhabdomyosarcoma

Abstract

A comparative study of 18 enolase and myoglobin as markers of muscle differentiation in rhabdomyosarcoma was carried out, using an immunoperoxidase peroxidase antiperoxidase technique. Material from 26 cases of childhood rhabdomyosarcoma was studied and subdivided into embryonal and alveolar types. Positive cytoplasmic staining for ,8 enolase was seen in 85% of tumours studied (91% alveolar, 79% embryonal), whereas positive staining for myoglobin was detected in only 69% of tumours (82% alveolar, 64% embryonal). ,B Enolase and myoglobin are useful in the histological diagnosis of rhabdomyosarcoma, and of the two, ,8 enolase seems to be the more sensitive.