Summary: Sulodexide is a glycosaminoglycan extracted from porcine intestinal mucosa. The purpose of this review is to discuss sulodexide's complex pharmacological profile and its clinical applications for venous disease. Sulodexide has wide-ranging biological effects on the vascular system, including antithrombotic, profibrinolytic, anti-inflammatory, endothelial protective and vasoregulatory effects. Sulodexide has emerged as a potential therapeutic option for the management of chronic venous insufficiency, including venous ulceration, and the prevention of recurrent venous thromboembolism, with a low rate of major bleeding complications. Sulodexide's pleiotropic vascular effects may facilitate the management of common venous disorders.
CITATION STYLE
Carroll, B. J., Piazza, G., & Goldhaber, S. Z. (2019, January 1). Sulodexide in venous disease. Journal of Thrombosis and Haemostasis. Blackwell Publishing Ltd. https://doi.org/10.1111/jth.14324
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