TPN (II): A traumatic case of increased metabolism: TPN, valproic acid

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Abstract

This case discusses increased clearance of the antiepileptic drug valproic acid in patients with traumatic brain injury during administration of total parenteral nutrition, resulting in subtherapeutic valproic acid levels.

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Wittwer, E. D., Nicholson, W. T., & Sprung, J. (2015). TPN (II): A traumatic case of increased metabolism: TPN, valproic acid. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 895–898). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_201

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