Evolving concepts of diagnosis and classification

Abstract

Systemic sclerosis (SSc) manifests with a heterogeneous array of immunologic, fibrotic, and vasculopathic features and is a disease lacking a single diagnostic test. The diagnosis is based on physician expertise and judgment. Classification criteria are used to distinguish individuals with SSc from other conditions so homogeneous groups of patients are included into studies. Classification criteria are also used to identify subsets of SSc. This chapter discusses the evolving concepts of diagnosis and classification in SSc.