Desmosomes in Human Disease

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Abstract

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.

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APA

Najor, N. A. (2018, January 24). Desmosomes in Human Disease. Annual Review of Pathology: Mechanisms of Disease. Annual Reviews Inc. https://doi.org/10.1146/annurev-pathol-020117-044030

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