Galectins are glycan-binding proteins which are expressed by many different cell types and secreted extracellularly. These molecules are well-known regulators of immune responses and involved in a broad range of cellular and pathophysiological functions. During infections, host galectins can either avoid or facilitate infections by interacting with host cells- and/or pathogen-derived glycoconjugates and less commonly, with proteins. Some pathogens also express self-produced galectins to interfere with host immune responses. This review summarizes pathogens which take advantage of host- or pathogen-produced galectins to establish the infection.
CITATION STYLE
Ayona, D., Fournier, P. E., Henrissat, B., & Desnues, B. (2020, August 19). Utilization of Galectins by Pathogens for Infection. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2020.01877
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