Association of chemokines receptor (CCR5 Δ32) in idiopathic recurrent miscarriages among north Indians

Abstract

Purpose: Human reproduction is a complex process involving multiple factors for the success of pregnancy. Chemokines are one of the immunomodulators which may determine pregnancy outcome. In the present study, we have tested genetic association between CCR5 Δ32 polymorphism and idiopathic recurrent miscarriages (IRM) among north Indians. Methods: Two hundred patients and 300 age, sex and ethnically matched controls were genotyped for CCR5 Δ32 polymorphism, genotype and allele frequencies were compared in both the groups. Results: IRM patients had a three times higher (5.5 vs. 1.7%) frequency of heterozygote genotype (P = 0.0335, OR = 3.43; 95% CI = 1.17-10.04). Allele frequency in IRM patients was 3.7 and 0.83% among controls and the differences were statistically significant (P = 0.0349, OR = 3.37; 95% CI = 1.16-9.76). Conclusions: Our results demonstrated that it had a higher frequency of CCR5 Δ32 at allelic level suggesting a possible susceptibility trend (OR = 3.43) and CCR5 Δ32 may be a potential genetic risk factor for IRM. © 2008 Springer-Verlag.