Parishin C, a major component of Gastrodia elata B LUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35 S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors. © 2010 The Japanese Pharmacological Society.
CITATION STYLE
Shin, E. J., Whang, W. K., Kim, S., Bach, J. H., Kim, J. M., Nguyen, X. K. T., … Kim, H. C. (2010). Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor. Journal of Pharmacological Sciences, 113(4), 404–408. https://doi.org/10.1254/jphs.10040SC
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