Efficacy and safety of low dose aspirin and magnesium sulfate in the treatment of pregnancy induced hypertension: A protocol for systematic review and meta-analysis

5Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background:Magnesium sulfate combined with low-dose aspirin can significantly reduce adverse reactions and effectively lower blood pressure in patients with pregnancy induced hypertension, but the overall efficacy and safety of the combination of drugs are not clear. The purpose of this study was to evaluate the efficacy and safety of magnesium sulfate combined with low-dose aspirin in the treatment of pregnancy induced hypertension.Methods:Randomized controlled trials focusing on the administration of magnesium sulfate combined with low-dose aspirin for pregnancy induced hypertension were searched from PubMed, EMbase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang, and the Chongqing VIP Chinese Science and Technology Periodical Database. Two researchers independently screened titles, abstracts, and full texts, and extracted relevant data. The RevMan 5.3 software and Stata 14 software were used for statistical analysis.Results:The effect and safety of magnesium sulfate combined with low-dose aspirin in the treatment of pregnancy induced hypertension were assessed by summarizing the related randomized controlled trials.Conclusion:This article provides theoretical support for the clinical application of magnesium sulfate combined with low-dose aspirin in the treatment of pregnancy induced hypertension.OSF Registration number:DOI 10.17605/OSF.IO/SZFGB.

References Powered by Scopus

Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015: Elaboration and explanation

9199Citations
N/AReaders
Get full text

The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed

2317Citations
N/AReaders
Get full text

Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings

99Citations
N/AReaders
Get full text

Cited by Powered by Scopus

An Overview of Obesity, Cholesterol, and Systemic Inflammation in Preeclampsia

29Citations
N/AReaders
Get full text

Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

4Citations
N/AReaders
Get full text

Caulis Spatholobi Ameliorates Pregnancy-Induced Hypertension in Mice by Regulating Hepcidin Expression and Iron Homeostasis

2Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

He, G., Chen, Y., Chen, M., He, G., & Liu, X. (2020, November 13). Efficacy and safety of low dose aspirin and magnesium sulfate in the treatment of pregnancy induced hypertension: A protocol for systematic review and meta-analysis. Medicine (United States). Lippincott Williams and Wilkins. https://doi.org/10.1097/MD.0000000000022801

Readers' Seniority

Tooltip

Researcher 4

57%

PhD / Post grad / Masters / Doc 3

43%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

56%

Pharmacology, Toxicology and Pharmaceut... 2

22%

Chemical Engineering 1

11%

Nursing and Health Professions 1

11%

Save time finding and organizing research with Mendeley

Sign up for free