E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

Abstract

Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.