Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.
CITATION STYLE
Cochrane, R. V. K., Alexander, F. M., Boland, C., Fetics, S. K., Caffrey, M., & Cochrane, S. A. (2020). From plant to probe: Semi-synthesis of labelled undecaprenol analogues allows rapid access to probes for antibiotic targets. Chemical Communications, 56(61), 8603–8606. https://doi.org/10.1039/d0cc03388j
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