From plant to probe: Semi-synthesis of labelled undecaprenol analogues allows rapid access to probes for antibiotic targets

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Abstract

Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.

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Cochrane, R. V. K., Alexander, F. M., Boland, C., Fetics, S. K., Caffrey, M., & Cochrane, S. A. (2020). From plant to probe: Semi-synthesis of labelled undecaprenol analogues allows rapid access to probes for antibiotic targets. Chemical Communications, 56(61), 8603–8606. https://doi.org/10.1039/d0cc03388j

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