Evaluation of Carrageenan induced anti-inflammatory activity of ethanolic extract of bark of Ficus virens Linn. in swiss albino mice

Abstract

The aim of the present study was to explore the probable anti-inflammatory activity of ethanolic extract of Ficus virens bark using Carrageenan induced inflammation in the mice. Swiss albino mice were treated orally with normal saline (as control group) and Ficus virens extract (200 and 400 mg/kg), 60 min before 0.1 mL 1% carrageenan injection. Paw volume was measured before and 1, 2, and 3 h after the injection of carrageenan. The results were expressed as the Mean ±SEM and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA) followed by Dunnett’s test. The sub plantar injection of carrageenan caused a time-dependent paw edema in the mice. Oral administration of Ficus virens extract (200 and 400 mg/kg) inhibited paw swelling dose-dependently at 1, 2, and 3, h after Carrageenan injection. We can conclude from the outcome of the present work that Ficus virens extract exert an excellent anti-inflammatory effect in the mice.