A commercially viable electrochemical sensor for the immunosuppressant drug mycophenolate mofetil utilizing pencil graphite electrode

Abstract

An electrochemical sensor facilitating the electro oxidation of the immunosuppressant, mycophenolate mofetil (MMF) on pencil graphite electrode (PGE) has been developed. The electrochemical characteristics of the electrode was evaluated by virtue of cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The PGE was characterized by XRD analysis and FE-SEM before and after the electrooxidation of MMF at the electrode. CV of MMF exhibited two irreversible oxidation peaks at about 0.66 V and 0.84 V. In the DPV studies, two linear ranges were observed towards the determination of MMF concentration from 20 nM - 300nM and 300 - 1000 nMin 0.1M phosphate buffer with pH 6. The limit of detection of the sensor was estimated to be 1.80nM. The proposed sensor exhibited acceptable selectivity for quantifying the MMF in pharmaceutical dosage forms and urine samples.