Association between high-flow nasal cannula and end-expiratory esophageal pressures in premature infants

28Citations
Citations of this article
64Readers
Mendeley users who have this article in their library.

Abstract

BACKGROUND: High-flow nasal cannula (HFNC) is commonly being used to provide noninvasive respiratory support in newborn infants. Continuous distending pressure generated by these devices in preterm infants has not been elucidated. The aim of this work was to determine the association between HFNC flow in L/min and end-expiratory esophageal pressure in cm H2O in premature infants. METHODS: In a prospective observational study, end-expiratory esophageal pressure measurements were conducted in clinically stable premature infants who required HFNC. The end-expiratory esophageal pressure generated by the HFNC was measured by a regular feeding tube overlying the lower esophagus and connected to a pressure transducer. Each infant had different end-expiratory esophageal pressure measurements at different high flows ranging from 2 to 8 L/min. RESULTS: Nineteen premature infants were studied. Their birthweight (mean ± SD) was 904 ± 574 g, and gestational age was 26.6 ± 3.1 weeks. Overall, 93 end-expiratory esophageal pressure measurements were conducted. At the time of the end-expiratory esophageal pressure measurements, infants were 1,458 ± 828 g and 7.2 ± 4.8 weeks old. At HFNC flows ranging from 2 to 8 L/min, the corresponding esophageal pressures ranged from 2 to 15 cm H2O. There was a statistically significant association between esophageal pressures and flows. In a linear regression model with the end-expiratory esophageal pressure as the dependent variable and HFNC flow as the independent variable, there was a significant correlation between the 2 variables: end-expiratory esophageal pressure (cm H2O) ± 1.18 ± HFNC (L/min) (r2 ± 0.95, P

References Powered by Scopus

Bronchopulmonary dysplasia

4246Citations
N/AReaders
Get full text

European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants-2013 update

408Citations
N/AReaders
Get full text

High-flow nasal cannulae in the management of apnea of prematurity: A comparison with conventional nasal continuous positive airway pressure

293Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Nasal high-flow therapy for newborn infants in special care nurseries

66Citations
N/AReaders
Get full text

Bronchopulmonary dysplasia: Rationale for a pathophysiological rather than treatment based approach to diagnosis

43Citations
N/AReaders
Get full text

High-Flow Nasal Cannula Use Outside of the ICU Setting

41Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Iyer, N. P., & Mhanna, M. J. (2016). Association between high-flow nasal cannula and end-expiratory esophageal pressures in premature infants. Respiratory Care, 61(3), 285–290. https://doi.org/10.4187/respcare.04317

Readers' Seniority

Tooltip

Researcher 10

34%

PhD / Post grad / Masters / Doc 9

31%

Professor / Associate Prof. 7

24%

Lecturer / Post doc 3

10%

Readers' Discipline

Tooltip

Medicine and Dentistry 23

72%

Nursing and Health Professions 5

16%

Agricultural and Biological Sciences 3

9%

Decision Sciences 1

3%

Save time finding and organizing research with Mendeley

Sign up for free