The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer. © Springer-Verlag 2007.
CITATION STYLE
Zogopoulous, G., Rothenmund, H., Eppel, A., Ash, C., Akbari, M. R., Hedley, D., … Gallinger, S. (2007). The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. Human Genetics, 121(5), 635–637. https://doi.org/10.1007/s00439-007-0361-z
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