FABRICATION OF CURCUMIN LOADED NANO POLYCAPROLACTONE/CHITOSAN NONWOVEN FABRIC VIA ELECTROSPINNING TECHNIQUE

Abstract

Cucurmin loaded poly e–caprolactone/chitosan (PCL/CTS) nanoscale nonwoven fabric was successfully fabricated using electrospinning, a facial and efficient method. The surface tensions of PCL/CTS blend solutions in various ratios were measured to evaluate the influence of PCL/CTS ratio on fibers formation. The effects of process parameter such as the applied voltage, tip–collector distance and the solution flow rate on the fiber generation and morphology of final fiber were optimized. Nanofibers morphology and structure were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. The prepared fibers had a smooth surface and fine morphology. The diameter of fibers ranges from 200  nm to 400 nm. The release kinetics of curcumin loaded samples were also analyzed via in vitro technique. Results demonstrated that the polycaprolactone/chitosan–based nanofibers encapsulate curcumin is a potential material for wound healing acceleration.